Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) Q4 2025 Earnings Call Transcript

Vertex Pharmaceuticals (NASDAQ:VRTX) reported Q4 and full-year 2025 financial results, with total revenue reaching $3.2 billion in Q4, a 10% increase year-over-year, and $12 billion for the full year, growing 9%. The company discussed strong performance in its CF franchise, successful launches of KASJEVY and Gernavix, and progress in its emerging renal pipeline, particularly with Povatacept for IgA nephropathy. Vertex provided 2026 revenue guidance of $12.95 billion to $13.1 billion, expecting significant contributions from non-CF products.

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